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transient impairment of glucose tolerance is possible, particularly in individuals with pre-existing insulin resistance Injection site reactions: Mild and typically localised Contraindications include active malignancy (GH-IGF-1 signalling can promote tumour growth), pituitary-dependent conditions, pregnancy, and active diabetic retinopathy

The synergistic application of these orthogonal methodologies affords unprecedented insights into Klas physiological and pathological roles across cellular contexts